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Pre-Alzheimer’s Test – APOE & MTHFR Genetic Test

$199.00 $149.00

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Markers tested: APOE, MTHFR genes

The test will check APOE and MTHFR gene markers that are associated with the risk of developing Alzheimer’s disease, dementia, and cardiovascular diseases.

FREE Shipping both ways and a physician reviewed report from world-class CLIA-certified labs.

Easy, Fast, Reliable and requires just a few steps:

1. Order Online

2. Receive The Kit And Collect Sample At Home

3. Ship It Back For FREE To Our World-Class CLIA Labs

4. Receive Secure, Confidential, & Easy-To-Understand Report Within Days

Questions? Contact Us. Text: 971-205-2185 (9 am – 6 pm PST)



Test Details

At Home Test

What is an APOE and MTHFR Genetic Test?

APOE (apo-lipo-protein E) gene is associated with inheriting an increased risk of Alzheimer’s disease, dementia and cardiovascular diseases. Alzheimer’s is the third largest cause of death in America, after cardiovascular disease and cancer.

Everyone has two copies of APOE genes (one from each parent) and occur as E2, E3, and E4. The E4 version is associated with degenerate diseases such as dementia and Alzheimer’s. It has also been shown to increase chance of atherosclerosis, a plaque responsible for artery blockage. The E2 version has been shown to increase the risk of certain rare cardiovascular diseases.

MTHFR (methyele-tetra-hydro-folate reductase) is a gene responsible for helping our bodies make proteins.

It is specifically important to digest folate or vitamin B9, and helps regulate homocysteine levels.

The APOE and MTHFR Genetic Test is an at-home genetic test that checks for APOE genotype. The test uses a saliva swab for sample collection.

Why measure APOE and MTHFR?

Alzheimers frequency and age of onset

The APOE gene is a major genetic risk factor for early stage neuro-de-generative disease. Studies show that people carrying the E4 allele pair have a higher prevalence of Alzheimer’s disease (at 91%) and much lower mean age of onset (at 68 years of age). In comparison, for those carrying E2 pair, the rate is 20% and mean age at onset is 84 years.

The MTHFR gene is important for digesting vitamin B9, and for reducing homocysteine in blood. It is also important in the metabolism of methotrexate, a drug used in rheumatoid arthritis  and chemotherapy.

Read our detailed reports on:


How to check the risk of Alzheimer’s and cardiovascular disease at home?

You can order an easy, low-cost genetic test to assess your risk of cognitive decline without going to a doctor or lab. Order a test kit online, collect saliva  with few swabs, send the sample to our CLIA-certified labs, and find out your risk of Alzheimer’s disease and dementia in few days.


Be informed, read more…

Our easy-to-read yet thoroughly researched articles provide data-driven information on some of the most common tests and the research behind them. You can read them anytime from the menu at the top.

Stay up-to-date on the latest news and research by following the Alzheimer’s Association. Learn more about APOE and MTHFR at the NIH Genetics Home Reference.


Q: Can I purchase the test across US?

A: Except New York, New Jersey, Rhode Island, and Maryland our tests are available in all 46 states. State regulations in NY, NJ, RI, and MD do not allow us to ship the tests to their residents.

Q: What does the kit contain and how do I use it?

A: The kit for our APOE and MTHFR Genetic Test contains few saliva swabs, instructions on how to collect the sample, and a form requesting basic information including date and time of collection. The directions are straight forward and easy to follow.

Q: How long does it take to receive the results?

A: You will receive the kit within 3-5 business days with a prepaid return envelope. After you ship the sample and it is received by our lab, you receive the results within 8-10 business days.

Q: What do I expect from the report?

A: The report with your test results will be easy to understand and will have all the necessary details. It will mark your genotype for Alzheimer’s and Cardiovascular diseases. It will briefly discuss what your numbers mean.

Q: Can I use my insurance to pay for the test?

A: You can use HSA (or FSA/MSA/HRA) accounts to pay for the tests since these are prescription tests (for further confirmation, please check the IRS publication#969). However, please ensure you are not going outside your specified max and min deductible limits. We do not have the capability to process the insurance claim. Insurance plans vary by individuals, therefore we can not guarantee your HSA payment will always be processed by your plan. Please talk to your insurance provider if you have any further concerns.

Q: How reliable are my results?

A: We have partnered with CLIA-certified labs that are used by physicians across the US. These labs are regulated by the states, as well as Centers for Medicare and Medicaid Services (CMS). Majority of the tests from these labs are FDA approved to ensure they meet the proper regulatory requirements. Additionally, the College of American Pathologists (CAP) requires inter-laboratory tests to ensure the ranges established by each lab do not drift or are not out of acceptable ranges. This is done by regularly testing reference samples between different labs. Finally, the labs test thousands of sample for different age groups and health conditions, and have well established reference data to compare your results against this large pool.

Q: Can you recommend what therapy should I take if my levels are high or low?

A: Unfortunately, no. As a lab test provider we can only test and report out data from your samples. We are not authorized to provide any medical recommendations. But we strongly encourage you to discuss the results with your doctor for next steps.

Reasons to Check

5 reasons to know your APOE and MTHFR genes:

  1. An at-home APOE and MTHFR genetic test ordered online from your home can help check your risk of cognitive decline as well as cardiovascular diseases.
  2. APOE, MTHFR genetic test from help understand the potential future risks of inherited diseases.
  3. Those with E4 version of APOE inherit an increased risk of developing early-onset of Alzheimer’s disease and can be checked with the APOE test.
  4. Our test can help you assess your genetic risk factors for cognitive decline, Alzheimer’s disease, and cardiovascular diseases right from the comfort of your home.
  5. Better health results in better quality of life, and a single at-home APOE, MTHFR genetic test from can offer insight not only into various health symptoms, but it can serve as a motivation to treat each of these symptoms and have a better quality of life!

Why with Us?

7 reasons to order an APOE Genetic Risk test kit from

No lab visits or doctor appointments
Saliva test (no finger pricks and blood sample)
World class CLIA-certified labs
Physician reviewed results
Fast, secure, and confidential reports
Free shipping
Qualifies for payment using HSA/FSA

Still wondering where to get an APOE and MTHFR Genetic test?

  • Each at-home health test from includes a physician’s prescription and review of the final results. All orders include a detailed report with your genetic test results explained clearly in a manner that you can understand. If you believe you might be observing a cognitive decline or has a family history, this low cost is test is the best way to find out.
  • is one of the best places to test as we process your tests at some of the best CLIA-Certified labs that other physicians use but no lab or doctor visit is required. So rest assured that your is being processed in a world class lab.
  • offers one of the best tests for Genetics, with convenient, confidential, and reliable results at some of the lowest prices in the market.
  • At-home APOE, MTHFR genetic test is quick and easy, can be ordered online, and doesn’t require a doctor’s visit or prescription. This saves time and money on visits to the doctor and the lab.
  • We use the latest technology and work hard to secure all your information and will never share it with third parties.


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